We analyzed the genome-wide association study (GWAS) data and found that TYK2, caspase recruitment domain family member 14 (CARD14) [15], NFK-BIA [19], TNFAIP3 [19], TNIP1 [19], IL-36RN [20], and other genetic polymorphisms in this pathway are associated with the pathogenesis of psoriasis. The gene discussed is TYK2; the disease is psoriasis.