In the crude analysis, minor homozygotes of SNP proxy rs12791871 for GWAS SNP rs12785878 (located in NADSYN1 in chromosome 11) also had a statistically significant decreased risk of breast cancer (OR 0.73, 95% CI 0.55–0.95) compared with major homozygotes (Table 2). The gene discussed is NADSYN1; the disease is breast cancer.