As previous studies showed that TNBC had more frequently PD-L1 expression [4, 5], anti-PD-L1/anti-PD-1 therapy has become a promising therapeutic strategy for TNBC, and several trials have shown that anti-PD-1 therapy was effective for breast cancer, and particularly TNBC [6, 7]. This evidence concerns the gene PDCD1 and breast cancer.