Not all SCN1A epileptic encephalopathies are Dravet syndrome: Early profound < r226Met phenotype Neurology Neurology 2017 2017 Aug 9 Aug 9 10.1212/WNL.0000000000004331 10.1212/WNL.0000000000004331. The gene discussed is SCN1A; the disease is encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.