Map3k14, a target of miR-7a-5p and miR-138-5p, mediates the neuron specific suppression of the nuclear factor κ-B (NF-kB; Mao et al, 2016) that is upregulated in epilepsy patients (Teocchi et al., 2013) and in an experimental model of traumatic brain injury (Lipponen et al., 2016). Here, MAP3K14 is linked to epilepsy.