NFE2L2 and cancer: Particularly, several drug efflux transporters are known to be under the control of NRF2: the expression of the multidrug resistance gene (MDR1), multidrug resistance-associated protein-1 (MRP1), and breast cancer resistance protein (BCRP) was upregulated in cancer cells with NRF2 overactivation, which led to chemoresistance [24–26].