Similarly to SKOV3 cells, NRF2-silenced renal carcinoma A498 (shNRF2-A498) retained reduced levels of c-MET, EGFR, p-c-MET, p-EGFR, p-AKT, and p-ERK1/2 when compared to those of the A498 control cells (Supplementary Figure 3 and Figure 1G-1H). This evidence concerns the gene AKT1 and renal carcinoma.