In agree with the results from in vitro experiments above, the expression levels of IGF-IR, IRS1 and VEGF from the tumor tissues of miR-143 expressing group were lower than those from miR-NC group (Figure 5D–5E), demonstrating that miR-143 acts as a tumor suppressor to inhibit tumor growth in PC cells, and IGF-IR and IRS1 are targets of miR-143 in vivo. The gene discussed is IRS1; the disease is neoplasm.