Although a trend towards association between smoking, an adverse prognostic risk factor, and ccRCC tumor TfR1 H-score did not reach significance (p = 0.053), smoking was significantly associated with a higher ccRCC tumor TfR1 maximum staining intensity (MSI) (mean 1.3 for smoking history vs. mean 1.0 for no smoking history; p = 0.022). This evidence concerns the gene TFRC and neoplasm.