Subsequent multivariate analysis results revealed that in addition to increasing age, KPS, grade and histology, high expression of ANXA2, ANXA2P1 and ANXA2P2 (HR: 1.883, P=0.002; HR: 2.444, P<0.001; HR: 2.053, P=0.001) were also the independent prognosis factors for survival of glioma samples (Table 1A and 1B). Here, ANXA2 is linked to central nervous system cancer.