Furthermore, Kaplan–Meier curve and Cox regression analyses showed that the high expression of ANXA2 and its pseudogenes were correlated with the poor OS of glioma patients, and the aberrantly expressed ANXA2, ANXA2P1 and ANXA2P2 were the independent prognosis factors for gliomas. This evidence concerns the gene ANXA2P2 and central nervous system cancer.