ANXA2 and central nervous system cancer: Furthermore, the Univariate Cox regression analysis of the OS of glioma samples within TCGA showed that high expression of ANXA2 and its pseudogenes (P<0.001), increasing age (P<0.001), high karnofsky performance score (KPS; P<0.001), WHO grade (II/IV, III/IV; both P<0.001), and histology (A/GBM, OD/GBM, OA/GBM; all P<0.001) were the factors associated with prognosis.