Moreover, multivariate logistic analysis revealed that lymphatic invasion (odds ratio [OR] 14.6851, 95% confidence intervals [CI] 4.7346–64.9051; P < 0.0001) and high ezrin expression (OR 2.3088, 95% CI 1.1513–4.7120; P = 0.0183) were independent predictors of LN metastasis in CRC patients (Table 2). This evidence concerns the gene EZR and colorectal carcinoma.