EZR and colorectal carcinoma: Furthermore, multivariate analysis identified advanced T stage (Hazard Ratio [HR] ( 3.5129, 95% CI 1.2079–127563; P = 0.0198), distant metastasis (HR 5.5591, 95% CI 2.2504–13.6501; P = 0.0003), poor differentiation/mucinous (HR 2.9620, 95% CI 1.1080–7.0463; P = 0.0319), and high ezrin protein expression (HR 2.3125, 95% CI 1.0214–4.8337; P = 0.0447) were independent prognostic factors for CRC patients (Table 3).