Univariate analysis showed that poor OS was significantly associated with large tumor size (P = 0.0217), advanced T stage (P = 0.0004), LN metastasis (P = 0.0008), distant metastasis (P = 0.0001), poor differentiation/mucinous (P = 0.0018), venous invasion (P = 0.0013), and high ezrin protein expression in CRC (P = 0.0124). The gene discussed is EZR; the disease is neoplasm.