EZR and colorectal carcinoma: Quantification of the intensity and extent of ezrin staining revealed that it was expressed at significantly higher levels in CRC than in normal mucosa (P < 0.0001; Figure 2C) and at significantly higher levels in stage IV CRC than in stage I, II, or III CRC (P = 0.0006, P = 0.0009, P = 0.0237, respectively; Figure 2D).