Univariate analysis identified significant associations between poor OS and advanced age (P = 0.0007), large tumor size (P = 0.0035), advanced T stage (P < 0.0001), LN metastasis (P < 0.0001), distant metastasis (P < 0.0001), lymphatic invasion (P = 0.0062), venous invasion (P = 0.0054), and high ezrin mRNA expression in CRC (P = 0.0262). This evidence concerns the gene EZR and neoplasm.