While two variants, NRAS Q61L and HRAS G13R, are present in the cBioPortal data, we detected G12D (10/123), G13D (5/123), and G60E (1/123) mutations in NRAS and G12S (13/123), G12D (4/123), G13D (3/123), and G13C (2/123) in HRAS. The mutational profile of tumor tissue based on cBioPortal data and that of cfDNA are different, possibly due to differences in genetic sources, as well as the ethnicity and stage of patients. The gene discussed is NRAS; the disease is neoplasm.