Similar patterns of genetic variants were detected in 20 squamous cell carcinoma patients (TP53 (55%), EGFR (20%), PTEN (20%), PIK3CA (20%), IDH2 (25%), BRAF (15%), HRAS (10%), VHL (10%), RET (10%), and KIT (10%)) (Figure 1C). The gene discussed is PIK3CA; the disease is squamous cell carcinoma.