(Figures 4G) These data suggest that celecoxib inhibits MUC2 production in vitro via GPCR/cAMP/PKA/CREB pathway regardless of cytotoxicity and provides a preclinical rational for the use of celecoxib to control the growth of mucinous tumors like PMP given its MUC2 suppressive and cytotoxic properties. This evidence concerns the gene MUC2 and mucinous neoplasm.