The cardiac hypertrophy exacerbated by Ang II in the diabetic OVE26 mice was confirmed by noticeably enlarged cardiomyocyte size and the up-regulated cardiac hypertrophic marker atrial natriuretic peptide (ANP) (Figure 2B and 2C respectively) although there was no significant difference in heart weight to tibia length ratio or fibrosis (Figure 2A and 2D respectively). This evidence concerns the gene NPPA and cardiac hypertrophy.