After having validated the dysregulation of MALAT1 and miR-205 in osteosarcoma, We then investigated their regulatory roles during osteosarcoma progression, and MALAT1 was significantly up-regulated by pMALAT1 and overexpression of MALAT1 dramatically promoted cell viability (Figure 3A and 3B), while siMALAT1-1 suppressed cell proliferation (Figure 3C). Here, MALAT1 is linked to osteosarcoma.