Concerning the molecular functions of miR-101 in cancers, Varambally et al. firstly demonstrated that miR-101 expression was reduced in prostate tumors and miR-101 inhibited the expression of Enhancer of zeste homolog 2 (EZH2), a mammalian histone methyltransferase that contributes to the epigenetic silencing of target genes and regulates the survival and metastasis of cancer cells (Varambally et al. [44]. The gene discussed is PRDM9; the disease is cancer.