EZH2 and neoplasm: Overexpression of methyltransferases in MM can drive malignant transformation through the silencing of TS genes/non-coding RNAs; in detail, trimethylation of histone H3 at lysine 27 (H3K27me3) or lysine 36 (H3K36me3), catalyzed by the methyltransferases EZH2 and MMSET respectively, leads to the silencing of established tumor suppressor miRNAs [23, 24].