Recent reports indicate that high MALAT1 expression levels predict poor prognosis of cancer patients [28, 29] and MALAT1 knock-down blocks epithelial to mesenchymal transition and triggers cell cycle arrest and apoptosis, associated to reduced binding of EZH2 to its target loci and consequent upregulation of EZH2-repressed genes [28, 29, 47]. This evidence concerns the gene EZH2 and cancer.