Importantly, the combination of BEZ235 (10 nM) and RAD001 (10 nM) effectively blocked PI3K/AKT/mTOR signaling in all tested SCLC cell lines, as indicated by almost complete blockade of p-4E-BP1, p-p70S6K and p-AKT expression in all SCLC cell lines tested (Figure 4). This evidence concerns the gene AKT1 and small cell lung carcinoma.