Ducker et al. reported that if p-4E-BP1 can be effectively inhibited by the mTOR inhibitor PP242, the colon cancer cells and patient-derived xenografts were PP242 sensitive; On the contrary, in PP242-resistant colon cancer cells and patient-derived xenografts, p-4E-BP1 was poorly inhibited by PP242 [19]. Here, EIF4EBP1 is linked to colonic neoplasm.