GRIK1 and neoplasm: After adjusting for hormonal exposure and status, disease stage, and molecular subtype, in our sample, SNPs on the ADRGL2 ( p = 0.005), ROBO1 ( p = 0.047), SNTG1 ( p = 0.040), and GRIK1 ( p = 0.006) genes are significant independent predictors of tumor response to paclitaxel treatment (Table 3).