Compared to the homozygous ancestral alleles for each gene, the genotype T/T of the rs371363 (ADRGL2, also known as LPHN2), the C/C alleles of the rs997274 (ROBO1), the G/T genotype of the rs318885 (SNTG1), and the A/A genotype of the rs363599 (GRIK1) are significantly associated with suboptimal tumor response, i.e. tumor growth after paclitaxel treatment (Table 3). The gene discussed is ADGRL2; the disease is neoplasm.