Finally, the male (1.661 [1.05–2.64]), higher NLR (1.61 [1.10–2.36]), positive HbeAg (1.47 [1.01–2.13]), higher AFP (1.64 [1.08–2.51]), larger tumor size (1.10 [1.05–1.14]), vascular invasion (MIVI vs negative, 1.76 [1.12–2.76], MAVI vs negative, 2.27 [1.50– 3.41]), and poorer ES differentiation (1.48 [1.03– 2.13]) were associated with the worse OS. This evidence concerns the gene AFP and neoplasm.