To better understand how cancer cells may benefit from this newly discovered WEE1 epigenetic activity, we mined our pY37-H2B chromatin immunoprecipitation (ChIP)-sequencing data for genes associated with oncogenesis; it revealed that pY37-H2B marks were deposited at an important tumor suppressor gene-the isocitrate dehydrogenase 2 (IDH2). Here, H2BC21 is linked to neoplasm.