However, the studies reporting the stimulation of HK2 expression by the HPV oncogenes were based on ectopic E6/E7 overexpression [11, 12] and it is not clear to which extent the E6/E7 concentrations generated in these experiments reflect the biological effects of the endogenous E6/E7 amounts generated in HPV-positive cancer cells. Here, HK2 is linked to cancer.