Thus, the recent reports demonstrating the potential of E6/E7 to stimulate expression of HK2 [11, 12] are intriguing, since they provide a direct connection between the HPV oncogenes and the expression of a key cellular enzyme responsible for the metabolic reprogramming and apoptotic resistance of cancer cells, which is linked to increased oncogenicity and decreased therapeutic sensitivity in the clinic. Here, HK2 is linked to cancer.