This study identified two potential new tumor suppression mechanisms of ZR30 not studied yet in ETSP-expressing GBM cells and their xenografts: 1) up-regulation of SEMA3B, which is a tumor suppressor gene for lung cancer, breast cancer, renal cancers, ovarian tumors, esophageal squamous cell carcinoma, and liver cancer [14-16], and 2) down-regulation of FOXM1, which is an oncogene with major roles in tumor growth, angiogenesis, invasion and metastasis [17]. This evidence concerns the gene SEMA3B and esophageal squamous cell carcinoma.