In an effort to develop a therapeutic agent to meet this unmet need, Zhou et al. dissected and engineered EGF-containing fibulin-like extracellular matrix protein (EFEMP1)’s functional modules/domains and created the EFEMP1-derived tumor suppressive protein (ETSP) that inhibits key oncogenic signaling pathways (e.g. EGFR, NOTCH signaling pathways) differentially activated by GBM functional cell subpopulations and their interaction with the tumor-promoting microenvironment (e.g. MMP2) [5]. This evidence concerns the gene EGFR and glioblastoma.