With propensity score adjustment, ATM was associated with lower rates of ischemic event (hazard ratio, 0.67; 95% confidence interval (CI), 0.62–0.97; P = 0.01) or ischemic stroke (hazard ratio, 0.70; 95% CI, 0.63–0.98; P = 0.03) compared with no modification. The gene discussed is ATM; the disease is ischemic stroke.