The observed combination of intellectual disability, corpus callosum hypoplasia, hydrocephalus, and talipes equinovarus is also reminiscent of the constellation of features seen in the L1CAM-associated (neural cell adhesion molecule L1 [MIM: 308840]) HSAS (hydrocephalus due to congenital stenosis of aqueduct of sylvius [MIM: 307000]) and CRASH (corpus callosum hypoplasia, retardation, adducted thumbs, spastic paraplegia, and hydrocephalus [MIM: 303350]) syndromes. This evidence concerns the gene L1CAM and Talipes equinovarus.