Several genetic forms of CMT are caused by mutations in proteins affecting mitochondrial function such as mitofusin 2 (MFN2), ganglioside‐induced differentiation‐associated‐protein 1 (GDAP1), heat shock protein beta 8 (HSPB8), and heat shock protein beta 1 (HSPB1) 77, suggesting that mitochondria are important in motor neurons. This evidence concerns the gene MFN2 and Charcot-Marie-Tooth disease.