HOXA10 and glioblastoma: For example, among other genes, SNORD34, SNORD35A, SNORA38B, and SNORA71A were comparably downregulated in a glioblastoma multiforme (GBM) cell line where expression of the developmental gene HOXA10 was silenced by siRNA treatment leading to a signal cascade that impaired the homologous recombination pathway and ultimately diminished temozolomide resistance [57].