The presence of hypertension (p = 0.03), low preoperative cardiac function (p <0.0001), high BNP levels (p = 0.01), and postoperative complications (p = 0.001) were significantly associated with the development of MACE, while age, the use of cardioprotective medications, and types of surgery were not associated with the incidence of MACE. The gene discussed is NPPB; the disease is Hypertension.