While high cell density has been reported to induce neuroendocrine transdifferentiation of prostate cancer cells, osteogenic and chondrogenic differentiation of human mesenchymal stem cells, and keratinocyte differentiation [37–40], expression of the differentiation markers CD41 and CD61 on SET-2 or MEG-01 cells did not increase as cell density increased. This evidence concerns the gene ITGB3 and Familial prostate cancer.