Data from quantitative histology indicated that, similar to what was observed for the other examined proteinopathies, male BMAA-exposed rats had a greater alpha-synuclein burden in the substantia nigra pars compacta than females, with males exposed to BMAA on PND3 having an average of 8.38% dopaminergic neurons in the substantia nigra pars compacta harbouring Lewy bodies compared to 6.92% in female rats exposed on PND3 (Figure 7E,F). This evidence concerns the gene SNCA and proteostasis deficiencies.