SNCA and Parkinson disease: Yeterian and Pandya [78] and Hanganu et al. [79] proposed that, since the most rostrodorsal extent of the caudate head of the dorsal striatum is connected to the dorsolateral prefrontal cortex, damage or dysfunction of the caudate nucleus (i.e., as a function of dopamine depletion in PD and, potential alpha-synuclein overexpression as discussed below) would coincide with damage to the prefrontal cortex.