MAPT and Alzheimer disease: Importantly, although some of the other AD models such as rotenone and MPTP do manifest some hyper-phosphorylated tau deposition [108,109], these aggregates represent ‘pre-tangles’ and do not progress to frank NFTs [108,110,111] making this neonatal BMAA model the only non-transgenic rodent model available that exhibits this key neuropathology of AD.