This BMAA model therefore exhibits Aβ, NFT of hyper-phosphorylated tau, pathological TDP-43 inclusions and Lewy bodies together with accompanied neuronal loss in relevant regions in the brain and spinal cord tissue of exposed rats, making it the only model to exhibit all of these histopathologies associated with ALS/PDC. This evidence concerns the gene MAPT and amyotrophic lateral sclerosis.