However, the association of hyperphosphorylated TDP-43 aggregation with hippocampal sclerosis, defined as severe neuronal loss coupled to microgliosis in the CA1 region (reviewed in [131]), as observed in rats neonatally exposed to BMA on particularly PND3, 4 and 5 in the current study, is commonly associated with age-related pathologies such as dementia and Alzheimer’s Disease [132]. This evidence concerns the gene TARDBP and early-onset autosomal dominant Alzheimer disease.