This group contains several proteins with highly confirmed involvement in PCa progression, such as Osteopontin (SPP1), Complement C3 (C3), Granulin (GRN), Clusterin (CLU), Phosphatidylethanolamine-binding protein 1 (PEBP1), protein S100A9, and Alpha-enolase (ENO1). Here, C3 is linked to posterior cortical atrophy.