NR1H4 and benign prostatic hyperplasia: Among the canonical pathways, the top significant association of the proteins that were altered in PCa was with the Acute Phase Response Signaling pathway (p = 1.97 × 10−9 for PCa vs. BPH and p = 1.51 × 10−12 for PCa vs. BC), followed by LXR/RXR activation and FXR/RXR activation pathways (Figure 3A).