Alpha-enolase (ENO1) in addition to its glycolytic function, is a multifunctional protein that is involved in several biological and pathophysiological processes, depending on its cellular localization: in the cytoplasm it is considered as an oncogene, while in the nucleus, its shorter isoform has been shown to bind to the c-myc promoter and function as a tumor suppressor [55]. The gene discussed is MYC; the disease is neoplasm.