Eight proteins (A2M, AHSG, C3, FGA, FGG, HPX, ITIH4, SERPING1) from our dataset are included in Acute Phase Response Signaling pathway from PCa vs. BPH comparison and 11 proteins (AMBP, APOA1, APOH, AHSG, C3, C4A, F2, FGA, FGG, HPX, ITIH4,) from PCa vs. BC comparison. The gene discussed is C4A; the disease is benign prostatic hyperplasia.