Similar splicing modulation was found for caspase-9 (Casp-9) in lung cancer cells, in which activated AKT phosphorylated SRSF1, thereby leading to exclusion of an exon 3,4,5,6 cassette and generation of the anti-apoptotic Casp-9b isoform [52]. This evidence concerns the gene AKT1 and lung carcinoma.