Following ultra violet (UV) irradiation or cisplatin treatment, for example, the stress-inducible alternative splice forms of mouse double minute 2 homolog (MDM2), MDM2-ALT1 and MDMX-ALT2, lack the p53-binding domain, and were detected in breast cancer cells as important modifiers of the p53-mediated cellular stress response [109]. Here, MDM2 is linked to breast cancer.