ANGPTL3 and metabolic syndrome: They demonstrate that hepatic miR-27b is responsive to lipid levels and regulates the expression of two key metabolic genes, angiopoietin-like 3 (ANGPTL3) and glycerol-3-phosphate acyltransferase 1 (GPAM), which have been previously implicated in the pathobiology of dyslipidemia [38,39].