Our previous studies have demonstrated that Hepatitis B virus X proteins [29], gankyrin [30], Yin Yang 1 (YY1) [31], and cannabinoid receptor 1 (CB1R) [32] induce the development of hepatic steatosis by increasing the transcriptional activity of lipogenic gene expression in adult zebrafish. The gene discussed is CNR1; the disease is Hepatic steatosis.