We confirmed (Garofalo et al., 2015) that in the brain of EE mice, there is an increased frequency of NK cells expressing granzyme B and IFN-γ (see Figure 3—figure supplement 1b), and this leads to an increased degranulation of NK cells ex vivo (not shown) which was further increased when challenged against tumor cells (GL261 and YAC-1 cells, Figure 3d). The gene discussed is GZMB; the disease is neoplasm.