Based on the total populations, there was no significant association between XRCC1 gene Arg280His polymorphism and pancreatic cancer risk (allelic model, OR 0.956, 95% CI 0.589–1.550, P = 0.854; heterozygous model, OR 0.772, 95% CI 0.592–1.008, P = 0.057; homozygous model, OR 1.216, 95% CI 0.630–2.349, P = 0.560; dominant model, OR 0.885, 95% CI 0.565–1.385, P = 0.592; recessive model, OR 1.261, 95% CI 0.653–2.432, P = 0.490). The gene discussed is XRCC1; the disease is familial pancreatic carcinoma.