However, based on the HWE, there was significant association between XRCC1 gene Arg280His polymorphism and pancreatic cancer risk (allelic model, OR 0.743, 95% CI 0.576–0.958, P = 0.022; heterozygous model, OR 0.701, 95% CI 0.525–0.936, P = 0.016; dominant model, OR 0.710, 95% CI 0.537–0.939, P = 0.016). This evidence concerns the gene XRCC1 and familial pancreatic carcinoma.