Mechanistically, we found that RTL1 did not directly affect the expression of β-Catenin; instead, it increased the protein level of β-Catenin in melanoma cells by regulating the expression of DOCK4 and MACF1, both of which enhance the release of β-Catenin from the destruction complex and increase the stability of β-Catenin [36]. This evidence concerns the gene RTL1 and melanoma.