PRKAB1 and oncocytic adenoma: Consistent with the previous studies [16], AMP-activated protein kinase (AMPK) plays crucial roles in oncocytoma genesis, and this complex along with the mutation in its non-catalytic subunit PRKAB1 could be involved in the progression of renal oncocytoma, as it governs the catabolic state upon stress by switching off many ATP-consuming processes.