Among the putative complexes compiled, 37 complex subunits with mutations relevant to renal oncocytomas were currently functionally unannotated in CORUM (a manually curated repository of experimentally characterized human protein complexes), whereas the remaining macromolecular assemblies includes, for example, those implicated in cellular metabolism (e.g. Artemis/DNA-dependent protein kinase- [25], pyruvate dehydrogenase-, succinyl-CoA synthetase complexes, and oncocytoma genesis (e.g. missense mutations in DCLRE1C and frame shift mutations in PRKAB1). Here, PRKAB1 is linked to oncocytic adenoma.