The pathways “cell-cell communication” and “muscle contraction” were significantly down-regulated in renal oncocytomas (p-value ≤ 0.05; Table 1), consisting of protein members such as myosin, tropomyosin, collagens, vinculin, talin, caldesmon, and vimentin, the latter serving as a marker to differentiate renal oncocytomas from renal cell carcinoma [42]. The gene discussed is VCL; the disease is renal cell carcinoma.