In 2002, Tanabe at al. [45] showed that CXCR4 is overexpressed in 72% cases of feline mammary adenocarcinomas and 10 years later, Ferrari and et al. [46] demonstrated that SDF-1/CXCR4 axis has a proliferative role in feline mammary carcinoma cells. This evidence concerns the gene CXCR4 and breast carcinoma.