PRKN and Parkinson disease: TRIM24, one of nuclear localization protein involved in the transcription control of some nuclear receptors, has been found reduced in the peripheral blood and skin explants from parkinsonians [42], directly regulates genes in lipid metabolic, inflammation and damage pathways [43], acts negatively as a p53 (repressed by parkin in PD) regulator and leads to p53-induced apoptosis when depletion of TRIM24 in animal model [44–46].