The NADPH oxidase (NOX) family consisting of NOX1-5 and dual oxidase (DUOX) 1 and 2, are well established producers of ROS [26], with NOX2 and NOX4 playing a central role in the increased production of hydrogen peroxide (H2O2) in AML [23, 27, 28]. Here, CYBB is linked to acute myeloid leukemia.