HSPB1 and neoplasm: More tumor regression by J2 combination with taxol was observed in vivo tumor cells xenograft model, while HSP16 was not (Figure 6D), suggesting quinolone structure may be a pharmacophore for induction of altered HSP27 cross linking, because in the case of pyridine which is the replacement oxygene radical of pyrone residue for chromone to nitrogen, altered HSP27 cross linking activity was disappeared.