With the growing evidence on the oncogenic role of agrin in regulating focal adhesion integrity and its mechanistic role in tumor microenvironment during hepatocarcinogenesis [12–14], it is plausible that agrin may have a significant role in providing oncogenic microenvironment to the PDGF-stimulated HSCs and HCC development in liver cirrhosis. This evidence concerns the gene AGRN and hepatocellular carcinoma.