Given the striking decrease of plasma cells content in the tumor tissue that we observed in this study we hypothesize that this could be the result of depletion of B cells maturation signals maintained by TACI and BCMA. Significant downregulation of IL6R with retention/upregulation of IL-6 expression observed in our study suggests that so called IL-6 trans-signaling plays an important role in CRC [26]. This evidence concerns the gene IL6 and neoplasm.