IL6 and colorectal carcinoma: A possible meaning of IL-6 trans-signaling in CRC has been recently provided by Tseng-Rogenski et al. who have shown that IL-6 regulates localization of hMSH3 protein which in turn contributes to carcinogenesis by formation of microsatellite alterations at selected tetranucleotide repeats (EMAST) in 60% of CRCs [27].