CD27 and colorectal carcinoma: As shown in Figure 3AIL6R (interleukin-6 receptor), TNFRSF17 (BCMA, B cell maturation antigen), TNFRSF13B (TACI, Cyclophilin ligand interactor) and CD27 genes, that belong to immune stimulatory class showed concordant downregulation across all CRC clusters.