As shown in Figure 3AIL6R (interleukin-6 receptor), TNFRSF17 (BCMA, B cell maturation antigen), TNFRSF13B (TACI, Cyclophilin ligand interactor) and CD27 genes, that belong to immune stimulatory class showed concordant downregulation across all CRC clusters. Here, IL6R is linked to colorectal carcinoma.