The percentage of apoptotic U251 cells also significantly increased following RDH10-shRNA treatment compared with Scr-shRNA (12.04 ± 1.12 % vs 1.67 ± 0.12%, respectively; P = 0.0036) (Figure 3D), indicating that RDH10 may have an anti-apoptotic role in glioma cells. Here, RDH10 is linked to central nervous system cancer.