The results suggested that EC progression was strongly associated with (1) cell proliferation, survival, invasion, metastasis and angiogenesis (MAPK signaling pathway, cell cycle, wnt signaling pathway, VEGF-signaling pathway, MMP1, SPP1, COL11A1), (2) cell adhesion (focal adhesion, adhesion junction, calcium signaling pathway, PTK2),(3) the imbalance of oncogene and cancer suppressor gene (p53 signaling pathway, pathway in cancer, MET, PLCD1) as well as(4) the participation of the immune system (IL8, CXCR7). This evidence concerns the gene ACKR3 and cancer.