Univariate analysis showed that gender (p < 0.0001), HBV viral load (p < 0.0001), ALT (p = < 0.0001), mutation from K to M at amino acid (aa) 130 (p = 0.002) and V to I at aa131 (p = 0.042) had a significant positive correlation when the IC group was compared with AC+LC+HCC (Table 4). The gene discussed is GPT; the disease is hepatocellular carcinoma.