In this study, we examined the expression of EYA1 in a spectrum of melanocytic and non-melanocytic neoplasms of the skin, investigated its correlation with clinical-pathological parameters of melanoma, characterized its functional role in melanoma cells, and evaluated the therapeutic potential of EYA1 inhibitor benzbromarone as a therapeutic agent for melanoma cells. The gene discussed is EYA1; the disease is melanocytic neoplasm.