HPSE and breast carcinoma: Breast carcinomas overexpress a broad range of TAA which can be recognized by endogenous effector and regulatory T cells [9–11], including carcinoembryonic antigen (CEA), the melanoma-associated antigen (MAGE)-A3, mucin (MUC)-1, the human epidermal growth factor receptors EGFR and HER2, mammaglobin A and heparanase (HPA).