Several targets of miR-204-5p have been confirmed in various cancers, such as EZRIN [33, 34], BCL-2 [23], FOXC1 [35], MEIS1 [36], RAB22A [37], NAUKI [20], SIRT1 [38], LC3B [39], PRKR-Like ER Kinase (PERK) [40], MX1 and TXNIP [41], snai1 [42], FOXM1 [43], ATF2 [44], JAK2 [45], etc. Notwithstanding, a single miRNA always functions through numerous targets, even an extremely large gene network. This evidence concerns the gene SIRT1 and cancer.