The reasons may be that 1) miR-204-5p expressed heterogeneously in different cancers, 2) the regulatory mechanisms which miR-204-5p participated in may be cancer-specific, 3) the aberrant genes in different cancers may be inconsistent, since APC in colorectal cancer and p16 in glioma, which may lead to a different status of miR-204-5p in cancers. The gene discussed is APC; the disease is cancer.