For example, the disintegrin and metalloproteinase 10 (ADAM 10) has been shown to regulate the cleavage and shedding of CXCL16 [24], and it was also demonstrated that ADAM 10 regulates the proliferation, invasion and chemoresistance of bladder cancer cells [25]. The gene discussed is CXCL16; the disease is urinary bladder carcinoma.