Among the genes found down-regulated in the specimens obtained from lymph node positive patients, the NQO1 gene encodes the phase II drug-metabolizing enzyme NAD(P)H:quinine oxidoreductase 1 (NQO1) and is considered significant for susceptibility to general carcinogenesis, and the genomic mutation in NQO1 is frequently found in cancer of colon, bladder, lung and pediatric leukemia. Here, NQO1 is linked to leukemia.