Interestingly, also the NEFL gene (encoding the light chain neurofilament protein and involved in cell death, GO:0008219; intermediate filament organization, GO:0045109) was found to be under-expressed in OSCC specimens with lymph node involvement: it seems congruent with its role in the promotion of apoptosis and prevention of cancer invasion, as previously reported in head and neck squamous cell carcinoma cell lines [31]. Here, NEFL is linked to cancer.