MMP10 and neoplasm: In OSCC specimens obtained from lymph node positive subjects we found downregulation of SERPINB11 and MMP10, and our data are in agreement with reports showing down-regulated expression of SERPIN genes located on chromosome 18q21 in OSCC [47], and the reliability of MMPs as molecular markers for monitoring progression from normal tissue to dysplasia and OSCC more than to invasive behavior of tumor cells [48].